Ketoconazole Allergy

Drug hypersensitivity reactions are adverse reactions to drugs that were administered at a dose that is tolerated by normal subjects, but produce symptoms that, from a clinical perspective, resemble an allergy. The revised nomenclature for allergies classifies hypersensitivity reactions to drugs as either allergic or non allergic. Drug allergies occur when immunologic mechanisms have been demonstrated. Allergic reactions caused by antifungal drugs are not frequently reported in clinical practice. Until now, the pathogenesis of hypersensitivity reactions to ketoconazole and other azole derivatives is unknown. Herein, we report an immediate reaction to ketoconazole and review the usefulness of a drug provocation test for diagnosis.